Project proposal Research Example | Topics and Well Written Essays - 3000 words

Project - Research Proposal Example These agents are known to possess a wide variety of applications, which can facilitate various non-viral systems for the introduction of DNA into the host body and enable easy and effective genetic therapy for the cure of dreaded diseases such as cancer. This study, attempts to identify and illustrate third generation polylysine dendrons as a potential source for the development of a non-viral platform for gene delivery. The study will delineate the characteristics of various dendrons to demonstrate their potential as a non-viral source of gene delivery. In addition, it will also illustrate the specific traits of third generation polylysine for potential use in gene delivery and gene therapy. To establish this, the study will comprise lab testing of mice to show that gene delivery can be efficiently be done using third generation polylysine dendrons. The goal of the research is to add value to the existing body of knowledge in this regard and to make it a more effective system for gene delivery as well as gene therapy. While the use of viral-vectors is an efficient method to introduce genes into host cells, they entail several cellular as well as extra cellular barriers. Though viral-vectors have both efficiency and high gene expression they ail from the major limitation of vulnerability to immunogenic reactions. Therefore, the medical fraternity’s interest rather slants to the alternative method of deploying non-viral methods for the delivery of genes into the host body as it entails lesser complexity. Thus, the use of dendrons or dendrimers has been gaining popularity in the field of genetic medicine, especially in its application for gene delivery and gene therapy. This is especially so because they provide a multifunctional platform by virtue of being synthetically capable of attaching tumour-targeting antibodies. Many studies confirm the validity of third generation polylysine as an effective monomer that has the potential to deliver